Product Description

MST-3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2861-50, ES2861-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases, the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: STK24, MST3, STK3, Serine/threonine-protein kinase 24, Mammalian STE20-like protein kinase 3, MST-3, STE20-like kinase MST3

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human STK24. AA range:319-368

Isotype: IgG

Target: MST3

Specificity: MST-3 Polyclonal Antibody detects endogenous levels of MST-3 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Isoform A is ubiquitous, Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex,

Observed Band (KD): 50kD

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein
Cofactor: Manganese. Only isoform A requires manganese
Function: Protein kinase that act on both serine and threonine residues
PTM: Autophosphorylated. Isoform B is activated by phosphorylation by PKA
Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
Similarity: Contains 1 protein kinase domain
Tissue Specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex

Subcellular Location: Cytoplasm Nucleus Membrane The truncated form (MST3/N) translocates to the nucleus Colocalizes with STK38L in the membrane

Storage and Stability: -20°C/1 year

Gene Name: STK24

Protein Name: Serine/threonine-protein kinase 24

Mouse Gene ID: 223255

Mouse SwissProt Number: Q99KH8

Rat Gene ID: 361092

Rat SwissProt Number: B0LT89

Research Use Only