Product Description

mtTFA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7375-50, ES7375-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

Reactivity: Human, Rat, Mouse,, Bovine

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: TFAM, TCF6, TCF6L2, Transcription factor A, mitochondrial, mtTFA, Mitochondrial transcription factor 1, MtTF1, Transcription factor 6, TCF-6, Transcription factor 6-like 2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TFAM. AA range:131-180

Isotype: IgG

Target: mtTFA

Specificity: mtTFA Polyclonal Antibody detects endogenous levels of mtTFA protein.

Dilution: WB 1:500-2000, Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Lymphocyte, Pooled, Uterus,

Observed Band (KD): 22kd

Fields: Apelin signaling pathway, Huntington disease

Function: Function: Involved in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA
Similarity: Contains 2 HMG box DNA-binding domains
Subunit: Interacts with TFB1M and TFB2M

Subcellular Location: Mitochondrion Mitochondrion matrix, mitochondrion nucleoid

Storage and Stability: -20°C/1 year

Gene Name: TFAM

Protein Name: Transcription factor A mitochondrial

Mouse SwissProt Number: P40630

Research Use Only