Product Description

Na+ CP type VIIIα Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60365-50, BS60365-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The sodium channel protein type 8 subunit alpha (Na+ CP type VIIIα) is a mμlti-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming α subunit, a noncovalently associated β1 subunit and a disμlfide-linked β2 subunit. The two β subunits regμlate the level of channel expression, modμlate gating and function as cell adhesion molecμles for cellμlar aggregation and cytoskeleton interaction. The α subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIα subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will resμlt in progressive paralysis and early death.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6, SCN8A, MED

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human Na+ CP type VIIIα.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Na+ CP type VIIIα polyclonal antibody detects endogenous levels of Na+ CP type VIIIα protein.

Molecular Weight: ~ 225 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UQD0

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only