Product Description

NDRG1 (phospho-Thr346) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14534-50, ES14534-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42)

Clonality: Polyclonal

Immunogen: Synthesized phosho peptide around human NDRG1 (Thr346)

Isotype: IgG

Target: NDRG1

Specificity: This antibody detects endogenous levels of Human Mouse Rat NDRG1 (phospho-Thr346)

Dilution: WB 1:1000-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous, expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues, Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas, Low levels in peripheral blood leukocytes and in tissues of the immune system, Expressed mainly in epithelial cells, Also found in Schwann cells of peripheral neurons, Reduced expression in adenocarcinomas compared to normal tissues, In colon, prostate and placental membranes, the cells that border the lumen show the highest expression,

Observed Band (KD): 43kD

Function: Disease: Defects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D) [MIM: 601455], also known as hereditary motor and sensory neuropathy Lom type (HMSNL). CMT4D is a recessive form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth dise

Subcellular Location: Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Cell membrane Mainly cytoplasmic but differentially localized to other regions Associates with the plasma membrane in intestinal epithelia and lactating mammary gland Translocated to the nucleus in a p53/TP53-dependent manner In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus No nuclear localization in colon epithelium cells In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate Associat

Storage and Stability: -20°C/1 year

Gene Name: NDRG1 CAP43 DRG1 RTP

Protein Name: NDRG1 (Thr346)

Mouse Gene ID: 17988

Mouse SwissProt Number: Q62433

Rat Gene ID: 299923

Rat SwissProt Number: Q6JE36

Research Use Only