Product Description

Net Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5102-50, ES5102-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation, studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],

Reactivity: Human, Mouse

Host: Rabbit

Applications: IF, ELISA

Alternate Names: ELK3, NET, SAP2, ETS domain-containing protein Elk-3, ETS-related protein ERP, ETS-related protein NET, Serum response factor accessory protein 2, SAP-2, SRF accessory protein 2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Elk3. AA range:323-372

Isotype: IgG

Target: Net

Specificity: Net Polyclonal Antibody detects endogenous levels of Net protein.

Dilution: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Epithelium, Placenta,

Molecular Weight (Da): 44kD

Function: Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element
Similarity: Belongs to the ETS family
Similarity: Contains 1 ETS DNA-binding domain
Subunit: Interacts with CTBP1

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: ELK3

Protein Name: ETS domain-containing protein Elk-3

Mouse Gene ID: 13713

Mouse SwissProt Number: P41971

Research Use Only