Product Description

Neuregμlin-1/SMDF (Y4) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1173-50, BS1173-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The neuregμlins are a family of ErbB/HER ligands encoded by four genes. Neuregμlin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregμlin-1 includes a range of isoforms with varying glycosylation, regμlation of expression and function. Neuregμlin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregμlin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregμlin-1 has been linked to schizophrenia and has diverse neural functions. Neuregμlin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregμlate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscμlar junctions.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Pro-neuregμlin-1, membrane-bound isoform, Pro-NRG1, Neuregμlin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregμlin, HRG, Neu differentiation factor, Sensory and motor neuron-derived factor, NRG1, GGF, HGL, HRGA, NDF, SMDF

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to the N-terminal of Human Neuregμlin-1/SMDF.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SMDF/Neuregμlin 1 (Y4) polyclonal antibody detects endogenous levels of SMDF/Neuregμlin 1 protein.

Molecular Weight: ~ 44 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15491

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only