Product Description

Neurexin I Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8030-50, ES8030-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: NRXN1, KIAA0578, Neurexin-1-alpha, Neurexin I-alpha

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551

Isotype: IgG

Target: Neurexin I

Specificity: Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain,

Observed Band (KD): 150kD

Function: cell morphogenesis, cell morphogenesis involved in differentiation, cell motion, cell adhesion, cell-cell signaling,synaptic transmission, axonogenesis, axon guidance, synaptogenesis, transmission of nerve impulse, biological adhesion, cell projection organization, neuron differentiation, neuron projection development, cellular component morphogenesis, cell part morphogenesis, extracellular structure organization, neuron development, cell morphogenesis involved in neuron differentiation, neuron projection morphogenesis, cell projection morphogenesis,synapse organization, neurological system process,

Subcellular Location: Cell junction, synapse, presynaptic cell membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: NRXN1

Protein Name: Neurexin-1-alpha

Mouse Gene ID: 18189

Mouse SwissProt Number: Q9CS84

Rat Gene ID: 60391

Rat SwissProt Number: Q63372

Research Use Only