Product Description

Neurexin IIIβ Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8028-50, ES8028-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: NRXN3 (neurexin 3) encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder.

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: NRXN3, KIAA0743, Neurexin-3-beta, Neurexin III-beta

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from Neurexin IIIβ. at AA range: 30-110

Isotype: IgG

Target: Neurexin IIIβ

Specificity: Neurexin IIIβ Polyclonal Antibody detects endogenous levels of Neurexin IIIβ protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in the blood vessel walls (at protein level),

Observed Band (KD): 70kD

Function: cell morphogenesis, cell morphogenesis involved in differentiation, regulation of neurotransmitter levels, generation of a signal involved in cell-cell signaling, neurotransmitter transport, cell motion, cell adhesion, cell-cell signaling, synaptic transmission, neurotransmitter secretion, axonogenesis, axon guidance, synaptogenesis, transmission of nerve impulse, biological adhesion, cell projection organization, neuron differentiation, neuron projection development,secretion by cell, cellular component morphogenesis, cell part morphogenesis, extracellular structure organization,secretion, neuron development, cell morphogenesis involved in neuron differentiation, neuron projection morphogenesis, cell projection morphogenesis, synapse organization, neurological system process,

Subcellular Location: Membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: NRXN3

Protein Name: Neurexin-3-beta

Mouse SwissProt Number: Q8C985

Research Use Only