NF κB P105/P50 Mouse Monoclonal Antibody (4D11) - RA11741

NF κB P105/P50 Mouse Monoclonal Antibody (4D11)

Size: 50μL, 100μL

Catalogue Numbers: RA11741-50, RA11741-100

Citations, Manuals and MSDS Available upon request.

Background: nuclear factor kappa B subunit 1 (NFKB1) Homo sapiens This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.60% sodium azide.

Storage Instructions: -20°C/1 year

Applications: IHC-p; WB

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 4790

Protein MW (KDa): 50+100

SWISS: P19838

Source: Mouse

Research Use Only