Product Description

NLRP3 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS45850-50, BS45850-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Enables DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regμlation of T-helper cell differentiation, positive regμlation of cytokine production, and response to bacterium. Acts upstream of or within several processes, including NLRP3 inflammasome complex assembly, activation of cysteine-type endopeptidase activity involved in apoptotic process, and defense response to virus. Located in cytoplasm and nucleus. Part of NLRP3 inflammasome complex. Is expressed in central nervous system and retina. Used to study CINCA Syndrome, familial cold autoinflammatory syndrome 1, and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome, Muckle-Wells syndrome, autosomal dominant nonsyndromic deafness 34, familial cold autoinflammatory syndrome 1, and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Category: Primary Antibody

Reactivity: Mouse

Host: Rabbit

Applications: WB, ICC/IF, IP

Alternate Names: FCU, MWS, FCAS, Cias1, Mmig1, NALP3, Pypaf1, AII/AVP, AGTAVPRL

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of mouse NLRP3

Dilution: WB: 1:1000 ICC/IF: 1:50 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 118 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8R4B8

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only