Product Description

NMDAζ1 (F891) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3721-50, BS3721-100

Sizes: 50µl, 100µl

Swiss-Prot: Q05586

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: NMDAζ1 (F891) polyclonal antibody detects endogenous levels of NMDAζ1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of NMDAζ1 (F891) pAb at 1:500 dilution
Lane 1: MCF-7 whole cell lysate (20ug)
Lane 2: Hela whole cell lysate (40ug)
Lane 3: PMVEC whole cell lysate (40ug)
Lane 4: AML-12 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of NMDAζ1 (F891) pAb in paraffin-embedded human brain tissue.

Bioworld Molecular Weight: ~ 105, 120 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Glutamate receptor ionotropic, NMDA 1; GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; GRIN1; NMDAR1

Immunogen: Synthetic peptide, corresponding to amino acids 860-910 of Human NMDAζ1.

Conjugate: Unconjugated

Modification: Unmodified