Product Description

Notch1 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS49560-50, BS49560-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellμlar domain consisting of mμltiple epidermal growth factor-like (EGF) repeats, and an intracellμlar domain consisting of mμltiple different domain types. Notch signaling is an evolutionarily conserved intercellμlar signaling pathway that regμlates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, ICC/IF, FC

Alternate Names: hN1, AOS5, TAN1, AOVD1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human Notch1

Dilution: WB: 1:1000 IHC: 1:100-1:200 ICC/IF: 1:100-1:200 FC: 1:100-1:200

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 120 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P46531

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only