Product Description

Nov Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4142-50, ES4142-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: NOV, CCN3, IGFBP9, NOVH, Protein NOV homolog, NovH, CCN family member 3, Insulin-like growth factor-binding protein 9, IBP-9, IGF-binding protein 9, IGFBP-9, Nephroblastoma-overexpressed gene protein homolog

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NOV. AA range:221-270

Isotype: IgG

Target: Nov

Specificity: Nov Polyclonal Antibody detects endogenous levels of Nov protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in endiothelial cells (at protein level) (PubMed:21063504), Expressed in bone marrow, thymic cells and nephroblastoma, Increased expression in Wilms tumor of the stromal type,

Observed Band (KD): 39kD

Function: Function: Immediate-early protein likely to play a role in cell growth regulation
Similarity: Belongs to the CCN family
Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
Similarity: Contains 1 IGFBP N-terminal domain
Similarity: Contains 1 TSP type-1 domain
Similarity: Contains 1 VWFC domain
Subunit: Interacts with FBLN1
Tissue Specificity: Increased expression in Wilms tumor of the stromal type

Subcellular Location: Secreted Cytoplasm Cell junction, gap junction Localizes at the gap junction in presence of GJA1

Storage and Stability: -20°C/1 year

Gene Name: NOV

Protein Name: Protein NOV homolog

Mouse Gene ID: 18133

Mouse SwissProt Number: Q64299

Rat Gene ID: 81526

Rat SwissProt Number: Q9QZQ5

Research Use Only