Product Description

Oncogene TIM Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7597-50, ES7597-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: ARHGEF5, TIM, Rho guanine nucleotide exchange factor 5, Ephexin-3, Guanine nucleotide regulatory protein TIM, Oncogene TIM, Transforming immortalized mammary oncogene, p60 TIM

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human ARHGEF5. AA range:191-240

Isotype: IgG

Target: Oncogene TIM

Specificity: Oncogene TIM Polyclonal Antibody detects endogenous levels of Oncogene TIM protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitously expressed with highest levels in placenta, High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland, In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624), Expressed at low levels in lung and heart (PubMed:14662653),

Observed Band (KD): 60kD

Function: Similarity: Contains 1 DH (DBL-homology) domain
Similarity: Contains 1 PH domain
Similarity: Contains 1 SH3 domain
Tissue Specificity: Mainly expressed in kidney, liver, pancreas, lung and placenta

Subcellular Location: Cytoplasm Nucleus Cell projection, podosome

Storage and Stability: -20°C/1 year

Gene Name: ARHGEF5

Protein Name: Rho guanine nucleotide exchange factor 5

Research Use Only