Product Description

ORP150 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS46480-50, BS46480-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resμlting in the accumμlation of this protein in the endoplasmic reticμlum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellμlar perturbation. This protein has been shown to be up-regμlated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resμlting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing resμlts in mμltiple transcript variants. [provided by RefSeq, Mar 2014]

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC, ICC/IF, FC, IP

Alternate Names: Grp170, HSP12A, ORP150, GRP-170, ORP-150

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human ORP150

Dilution: WB: 1:1000-1:5000 IHC: 1:50-1:200 ICC/IF: 1:50-1:200 FC: 1:20 IP: 1:20-1:50

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 150 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y4L1

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only