Product Description

OX2R Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3089-50, ES3089-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CD200R1, CD200R, CRTR2, MOX2R, OX2R, Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human MOX2R. AA range:241-290

Isotype: IgG

Target: OX2R

Specificity: OX2R Polyclonal Antibody detects endogenous levels of OX2R protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level), Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney, Expressed in monocyte-derived dendritic and mast cells,

Observed Band (KD): 37kD

Fields: Kaposi sarcoma-associated herpesvirus infection

Function: Function: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200
PTM: The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform
Similarity: Belongs to the CD200R family
Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
Subunit: Interacts with Human herpesvirus 8 vOX2 protein
Tissue Specificity: Expressed in granulocytes, monocytes, most T cells, neutrophils, basophils and a subset of NK, NKT and B cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells

Subcellular Location: [Isoform 1]: Cell membrane, Single-pass type I membrane protein, [Isoform 4]: Cell membrane, Single-pass type I membrane protein, [Isoform 2]: Secreted, [Isoform 3]: Secreted

Storage and Stability: -20°C/1 year

Gene Name: CD200R1

Protein Name: Cell surface glycoprotein CD200 receptor 1

Mouse SwissProt Number: Q9ES57

Research Use Only