Product Description

p21 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS46106-50, BS46106-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regμlator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimμli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regμlatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing resμlts in mμltiple transcript variants. [provided by RefSeq, Sep 2015]

Category: Primary Antibody

Reactivity: Mouse

Host: Rabbit

Applications: WB, IHC, ICC/IF, FC, IP

Alternate Names: P21, CDKI, CIP1, SDI1, Waf1, mda6, CAP20, Cdkn1, p21WAF, p21Cip1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of mouse p21

Dilution: WB: 1:1000 IHC: 1:200-1:500 ICC/IF: 1:200-1:500 FC: 1:20 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 18 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P39689

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only