P3C2A Polyclonal Antibody - BT-AP12644

P3C2A Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12644-20, BT-AP12644-50, BT-AP12644-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Research Areas: Immunology; Signal transduction

Target Protein: PIK3C2A

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O00443; Mouse: Q61194

Synonyms: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha;PI3K-C2-alpha;PtdIns-3-kinase C2 subunit alpha;EC 2.7.1.154;Phosphoinositide 3-kinase-C2-alpha

GeneID: Human: 5286

Research Use Only