Product Description

p57 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4072-50, ES4072-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF, ELISA

Alternate Names: CDKN1C, KIP2, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human p57Kip2 around the non-acetylation site of Lys278. AA range:241-290

Isotype: IgG

Target: p57

Specificity: p57 Polyclonal Antibody detects endogenous levels of p57 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis, Expressed in the eye, High levels are seen in the placenta while low levels are seen in the liver,

Observed Band (KD): 32kD

Fields: Cell cycle

Function: Disease: Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM: 130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors
Disease: Defects in CDKN1C are involved in tumor formation
Function: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life
Similarity: Belongs to the CDI family
Tissue Specificity: Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels ar

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: CDKN1C

Protein Name: Cyclin-dependent kinase inhibitor 1C

Mouse Gene ID: 12577

Mouse SwissProt Number: P49919

Research Use Only