Product Description

p70 S6 kinase β (phospho Ser423) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7097-50, ES7097-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ribosomal protein S6 kinase B2(RPS6KB2) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: RPS6KB2, STK14B, Ribosomal protein S6 kinase beta-2, S6K-beta-2, S6K2, 70 kDa ribosomal protein S6 kinase 2, P70S6K2, p70-S6K 2, S6 kinase-related kinase, SRK, Serine/threonine-protein kinase 14B, p70 ribosomal S6 kinase beta, S6K-beta, p70

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human p70 S6 Kinase beta around the phosphorylation site of Ser423. AA range:389-438

Isotype: IgG

Target: P70S6k

Specificity: Phospho-p70 S6 kinase β (S423) Polyclonal Antibody detects endogenous levels of p70 S6 kinase β protein only when phosphorylated at S423.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Epithelium, Lymph,

Observed Band (KD): 53kD

Fields: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, TGF-beta signaling pathway, Apelin signaling pathway, Fc gamma R-mediated phagocytosis, Thermogenesis, Insulin signaling pathway, Insulin resistance, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein
Function: Phosphorylates specifically ribosomal protein S6
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the protein kinase superfamily
Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
Similarity: Contains 1 AGC-kinase C-terminal domain
Similarity: Contains 1 protein kinase domain

Subcellular Location: Cytoplasm Nucleus

Storage and Stability: -20°C/1 year

Gene Name: RPS6KB2

Protein Name: Ribosomal protein S6 kinase beta-2

Mouse Gene ID: 58988

Mouse SwissProt Number: Q9Z1M4

Research Use Only