Product Description

PARK7 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3150-50, ES3150-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: PARK7, Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human DJ-1. AA range:21-70

Isotype: IgG

Target: PARK7

Specificity: PARK7 Polyclonal Antibody detects endogenous levels of PARK7 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart, Detected at slightly lower levels in placenta and brain (at protein level), Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa, Expressed by pancreatic islets at higher levels than surrounding exocrine tissues (PubMed:22611253),

Observed Band (KD): 22kD

Fields: Parkinson disease, Pathways of neurodegeneration - multiple diseases

Function: Disease: Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson disease 7 (PARK7) [MIM: 606324, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins),

Subcellular Location: Cell membrane, Lipid-anchor Cytoplasm Nucleus Membrane raft Mitochondrion Endoplasmic reticulum Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745) Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119) Membrane raft localization in astrocytes and neuronal cells requires palmitoylation

Storage and Stability: -20°C/1 year

Gene Name: PARK7

Protein Name: Protein DJ-1

Mouse Gene ID: 57320

Mouse SwissProt Number: Q99LX0

Research Use Only