PDE3A Polyclonal Antibody - BT-AP12871

PDE3A Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12871-20, BT-AP12871-50, BT-AP12871-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Areas: Signal transduction

Target Protein: PDE3A

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q14432; Mouse: Q9Z0X4; Rat: Q62865

Synonyms: cGMP-inhibited 3',5'-cyclic phosphodiesterase A;EC 3.1.4.17;Cyclic GMP-inhibited phosphodiesterase A;CGI-PDE A

GeneID: Human: 5139

Research Use Only