Product Description

PDLIM5 (phospho Tyr251) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4519-50, ES4519-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: PDLIM5, ENH, L9, PDZ and LIM domain protein 5, Enigma homolog, Enigma-like PDZ and LIM domains protein

Clonality: Polyclonal

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human PDLIM5 (phospho Tyr251)

Isotype: IgG

Target: PDLIM5

Specificity: Phospho-PDLIM5 (Y251) Polyclonal Antibody detects endogenous levels of PDLIM5 protein only when phosphorylated at Y251.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Heart and skeletal muscle specific, Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression,

Observed Band (KD): 64kD

Function: Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data
Disease: May play a role in genetic susceptibility to schizophrenia. PDLIM5 is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression
Function: May play an important role in the heart development by scaffolding PKC to the Z-disk region
Similarity: Contains 1 PDZ (DHR) domain
Similarity: Contains 3 LIM zinc-binding domains
Subunit: Interacts with various PKC isoforms through the LIM domains. Interacts with actin and alpha-actinin through the PDZ domain
Tissue Specificity: Heart and skeletal muscle specific

Subcellular Location: Cell junction, synapse, postsynaptic density Cell junction, synapse, presynapse Cell junction, synapse, postsynapse Cytoplasm, cytosol Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons

Storage and Stability: -20°C/1 year

Gene Name: PDLIM5

Protein Name: PDZ and LIM domain protein 5

Mouse SwissProt Number: Q8CI51

Research Use Only