Product Description

PEN2 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS46632-50, BS46632-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumμlation of gamma-secretase. Mutations resμlting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing resμlts in mμltiple transcript variants. [provided by RefSeq, Jμl 2013]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, ICC/IF, FC

Alternate Names: PEN2, PEN-2, MDS033, ACNINV2, MSTP064

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human PEN2

Dilution: WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:20-1:100

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 12 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NZ42

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only