Perforin Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A0093-20, A0093-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 61kDa
Observed Molecular Weight: 70kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 5551
SWISS: P14222
Alternate Names: P1; PFP; HPLH2; Perforin
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cell Biology Developmental Biology, Apoptosis, Immunology Inflammation, Cell Intrinsic Innate Immunity Signaling Pathway.
NCBI Alias: PRF1
Research Use Only