Product Description

PF-4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8634-50, ES8634-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014],

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: Platelet factor 4 (PF-4, C-X-C motif chemokine 4, Iroplact, Oncostatin-A) [Cleaved into: Platelet factor 4, short form]

Clonality: Polyclonal

Immunogen: Synthetic peptide from human protein at AA range: 51-100

Isotype: IgG

Target: PF-4

Specificity: The antibody detects endogenous PF-4

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Leukocyte,

Fields: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway

Function: Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form
mass spectrometry: PubMed: 7644496,mass spectrometry: Short form PubMed: 7644496,Online Information: CXCL4 entry,PTM: Binds non-covalently to a proteoglycan molecule
Similarity: Belongs to the intercrine alpha (chemokine CxC) family
Subunit: Homotetramer

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: PF4 CXCL4 SCYB4

Protein Name: Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form]

Mouse Gene ID: 56744

Mouse SwissProt Number: Q9Z126

Rat SwissProt Number: P06765

Research Use Only