Product Description

PGM5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14148-50, ES14148-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]).[supplied by OMIM, Mar 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human PGM5 AA range: 357-407

Isotype: IgG

Target: PGM5

Specificity: This antibody detects endogenous levels of PGM5 at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.145% sodium azide.

Expression: Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level, Present in other tissues due to vascular or other smooth muscle component, Low levels are present in liver, kidney, skin and brain (at protein level),

Observed Band (KD): 60kD

Function: Cofactor: Binds 1 magnesium ion per subunit
Function: Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity
Similarity: Belongs to the phosphohexose mutase family
Subcellular Location: Adherens-type cellular junctions
Subunit: Interacts with cytoskeletal proteins dystrophin and utrophin
Tissue Specificity: Expressed in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component

Subcellular Location: Cell junction, adherens junction Cytoplasm, cytoskeleton Cell membrane, sarcolemma Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments

Storage and Stability: -20°C/1 year

Gene Name: PGM5 PGMRP

Protein Name: PGM5

Mouse Gene ID: 226041

Mouse SwissProt Number: Q8BZF8

Research Use Only