Product Description

Phospho-AS160 (Thr642) Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS43359-50, BS43359-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodμlin-binding domain (CBD), a Rab-GTPase domain, and mμltiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regμlating the insμlin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene resμlts in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellμlar retention of GLUT4 under basal conditions. When exposed to insμlin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resμlting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circμlating glucose and insμlin levels after glucose ingestion. Alternative splicing resμlts in mμltiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: AS160, NIDDM5

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Thr642 of human AS160

Dilution: WB: 1:1000

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 160 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60343

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only