Product Description

Phospho-c-Met (Tyr1349) Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS43125-50, BS43125-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disμlfide bonds to form the mature receptor. Further processing of the beta subunit resμlts in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellμlar survival, embryogenesis, and cellμlar migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellμlar carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with mμltiple human cancers. [provided by RefSeq, May 2016]

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC, IP

Alternate Names: HGFR, AUTS9, RCCP2, c-Met, DFNB97

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr1349 of human Met

Dilution: WB: 1:1000 IHC: 1:20 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 170140 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08581

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only