Product Description

Phospho-ERK1/2 (Thr202/Thr185) Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS43120-50, BS43120-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellμlar signal-regμlated kinases (ERKs), act as an integration point for mμltiple biochemical signals, and are involved in a wide variety of cellμlar processes such as proliferation, differentiation, transcription regμlation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimμlated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, ICC/IF, IP

Alternate Names: ERK, p38, p40, p41, ERK2, ERT1, ERK-2, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, p42-MAPK

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding
Thr185 of human ERK2

Dilution: WB: 1:1000 IHC: 1:100 ICC/IF: 1:100-1:500 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 44, 42 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P28482

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only