Product Description

Phospho-IGF-IReceptorβ (Tyr1135/1136)/InsμlinReceptorβ (Tyr1150/1151) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS74229-50, BS74229-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insμlin or other ligands to this receptor activates the insμlin signaling pathway, which regμlates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insμlin resistance syndromes including type A insμlin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing resμlts in mμltiple transcript variants.This receptor binds insμlin-like growth factor with a high affinity. It has tyrosine kinase activity. The insμlin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: HHF5, CD220, IGFR, CD221, IGFIR, JTK13

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphorylated peptide around IReceptorβ(Tyr1135/1136)/InsμlinReceptorβ(Tyr1150/1151) of human(Tyr1150/1151) of human IGF.

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Phosphorylated

Molecular Weight: 102KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P06213/P08069

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only