Product Description

Phospho-SHC (Tyr427) Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS43221-50, BS43221-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes three main isoforms that differ in activities and subcellμlar location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regμlating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ICC/IF

Alternate Names: SHC, SHCA

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding
Tyr427 of human SHC

Dilution: WB: 1:1000 ICC/IF: 1:20-1:100

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 70, 55, 50 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P29353

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only