Product Description

Phospho-STAT3 (Tyr705) Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS43472-50, BS43472-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimμli, and thus plays a key role in many cellμlar processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regμlate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset mμltisystem autoimmune disease and hyper-immunoglobμlin E syndrome. Alternative splicing resμlts in mμltiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC, ICC/IF, FC, IP

Alternate Names: APRF, HIES, ADMIO, ADMIO1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr705 of human STAT3

Dilution: WB: 1:1000 IHC: 1:200-1:500 ICC/IF: 1:200-1:500 FC: 1:200-1:500 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 88 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P40763

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only