Product Description

PI3K p85β (Q496) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2827-50, BS2827-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110δ expression is restricted to white blood cells. It has been shown to bind p85α and p85β, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and βγ heterotrimeric G proteins.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Phosphatidylinositol 3-kinase regμlatory subunit beta, PI3-kinase regμlatory subunit beta, PI3K regμlatory subunit beta, PtdIns-3-kinase regμlatory subunit beta, Phosphatidylinositol 3-kinase 85 kDa regμlatory subunit beta, PI3-kinase subunit p85-beta, PtdIns-3-kinase regμlatory subunit p85-beta, PIK3R2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 471-520 of Human PI3K p85β.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PI 3-kinase p85β (Q496) polyclonal antibody detects endogenous levels of PI 3-kinase p85β protein.

Molecular Weight: ~ 85 kDa

Pathway: Regμlation of Actin Dynamics, Warburg Effect, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O00459

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only