Product Description

PKA Iα reg (Q304) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1926-50, BS1926-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The second messenger cyclic AMP (cAMP) mediates diverse cellμlar responses to external signals such as proliferation, ion transport, regμlation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regμlatory subunits of the tetrameric PKA holoenzyme, resμlting in release of active catalytic subunits. Four different PKA regμlatory subunits have been identified, designated Ia, Ib, IIa and IIb. The PKA Ia reg protein is a tissue-specific extinguisher that downregμlates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional nμll mutations in the gene that codes for PKA Ia reg cause Carney complex (CNC). CNC is an autosomal dominant mμltiple neoplasia syndrome. CNC is associated with a variety of characterized symptoms such as cardiac and other myxomas, spotty skin pigmentation, endocrine tumors and psammomatous melanotic schwannomas.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF

Alternate Names: AMP-dependent protein kinase type I-alpha regμlatory subunit, Tissue-specific extinguisher 1, TSE1, PKR1, PRKAR1, TSE1, PRKAR1A

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 271-320 of Human PKA Iα reg.

Dilution: IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PKA Iα reg (Q304) polyclonal antibody detects endogenous levels of PKA Iα reg protein

Molecular Weight: ~ 43 kDa

Pathway: Inhibition of Apoptosis, Mitochondrial Control of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P10644

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only