PLCγ1 (phospho-Ser1248) Rabbit Polyclonal Antibody - RA28877

PLCγ1 (phospho-Ser1248) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28877-50, RA28877-100

Citations, Manuals and MSDS Available upon request.

Background: phospholipase C gamma 1 (PLCG1) Homo sapiens The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor) -activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:1000-2000

Alternative Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)

Applications: WB

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 5335

Protein MW (KDa): 150

SWISS: P19174

Source: Rabbit

Research Use Only