PLCγ2 (phospho-Tyr759) rabbit pAb - ES14068

PLCγ2 (phospho-Tyr759) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES14068-50, ES14068-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate to 1D-myo-inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],

Alternate Name: 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)

Source: Rabbit

Applications: WB; IF; ELISA; IHC

Dilution: WB 1:500-2000; IF/ICC 1:50-200; ELISA 1:2000-20000; IHC-p 1:50-200

Reactivity: Human; Mouse

Immunogen: Synthesized phosho peptide around human PLCγ2 (Tyr759)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 148kD

Human Gene ID: 5336

Human SWISS Prot NO: P16885

Subcellular Location: intracellular, cytosol, plasma membrane, extracellular exosome,

Research Use Only