PLN Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A17964-20, A17964-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca (2+) -ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse, Rat
Protein Weight: 6kDa
Observed Molecular Weight: 6kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 5350
SWISS: P26678
Alternate Names: PLB; CMD1P; CMH18; PLN
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:100 - 1:500 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Neuroscience, Calcium Signaling, Cardiovascular, Heart, Contractility.
NCBI Alias: PLN
Research Use Only