Product Description

POT1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3245-50, ES3245-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: protection of telomeres 1(POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008],

Reactivity: Human, Monkey

Host: Rabbit

Applications: WB, IHC

Alternate Names: POT1, Protection of telomeres protein 1, hPot1, POT1-like telomere end-binding protein

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human POT1. AA range:247-296

Isotype: IgG

Target: POT1

Specificity: POT1 Polyclonal Antibody detects endogenous levels of POT1 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous,

Observed Band (KD): 70kD

Function: Alternative Products: A number of isoforms are produced,Function: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and

Subcellular Location: Nucleus Chromosome, telomere Colocalizes with telomeric DNA

Storage and Stability: -20°C/1 year

Gene Name: POT1

Protein Name: Protection of telomeres protein 1

Mouse SwissProt Number: Q91WC1

Research Use Only