Product Description

PR48 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5573-50, ES5573-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC

Alternate Names: PPP2R3B, PPP2R3L, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta, PP2A subunit B isoform PR48, Protein phosphatase 2A 48 kDa regulatory subunit

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human PPP2R3B. AA range:364-413

Isotype: IgG

Target: PR48

Specificity: PR48 Polyclonal Antibody detects endogenous levels of PR48 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Placenta, Testis,

Observed Band (KD): 70kD

Fields: mRNA surveillance pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Human papillomavirus infection

Function: Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes
Similarity: Contains 1 EF-hand domain
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: PPP2R3B

Protein Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

Research Use Only