Product Description

PROF2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11790-50, ES11790-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: PROF2

Specificity: PROF2 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver,

Observed Band (KD): 15kD

Fields: Rap1 signaling pathway, Regulation of actin cytoskeleton, Amyotrophic lateral sclerosis, Shigellosis, Salmonella infection

Function: Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG
Similarity: Belongs to the profilin family
Subunit: Occurs in many kinds of cells as a complex with monomeric actin in a 1: 1 ratio
Tissue Specificity: Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver

Subcellular Location: Cytoplasm, cytoskeleton

Storage and Stability: -20°C/1 year

Gene Name: PFN2

Protein Name: Profilin-2 (Profilin II)

Mouse SwissProt Number: Q9JJV2

Rat SwissProt Number: Q9EPC6

Research Use Only