PSMC2 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A1985-20, A1985-100
Citations, Manuals and SDS Available upon request.
Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: S7; MSS1; RPT1; Nbla10058; PSMC2
GeneID: 5701
Swiss-Prot: P35998
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 49kDa
Observed Molecular Weight: 49kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PSMC2 (NP_002794.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Research Areas: Cell Biology Developmental Biology, Ubiquitin
Recommended Dilutions: WB: 1:500 - 1:2000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Nucleus, P-Body
Positive Samples: HepG2, SW620, BT474, DUCAR3, 293T, mouse spleen, mouse brain, rat testis, rat liver, BT-474, OVCAR3, NCI-H460
Keywords: 5701, sc-74872, sc-74874, sc-133932, sc-98691, MSS1, Nbla10058, Protein MSS1, PSMC2, S7, proteasome 26S subunit, ATPase 2, 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, mammalian suppressor of sgv-1 of yeast, protease 26S subunit 7, proteasome (prosome, macropain) 26S subunit, ATPase, 2, putative protein product of Nbla10058, testis secretory sperm-binding protein Li 197a, P35998, Proteasome 26S Subunit, Proteasome (Prosome, Macropain) 26S Subunit, Mammalian Suppressor Of Sgv-1 Of Yeast, 26S Proteasome AAA-ATPase Subunit RPT1, Putative Protein Product Of Nbla10058, Protease 26S Subunit 7, Testis Secretory Sperm-Binding Protein Li 197a, 26S Proteasome Regulatory Subunit 7, 26S Protease Regulatory Subunit 7, Proteasome 26S Subunit ATPase 2, sc74872, sc 74872, sc74874, sc 74874, sc133932, sc 133932, sc98691, sc 98691
Symbol: PSMC2
Category: Polyclonal Antibodies
Research Use Only