PTN13 Polyclonal Antibody - BT-AP13382

PTN13 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13382-20, BT-AP13382-50, BT-AP13382-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, ha

Research Areas: Cancer; Cell biology; Signal transduction

Target Protein: PTPN13

Applications: IHC-p, IF

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Tyrosine-protein phosphatase non-receptor type 13

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q12923; Mouse: Q64512

Synonyms: Tyrosine-protein phosphatase non-receptor type 13;EC 3.1.3.48;Fas-associated protein-tyrosine phosphatase 1;FAP-1;PTP-BAS;Protein-tyrosine phosphatase 1E;PTP-E1;hPTPE1;Protein-tyrosine

GeneID: Human: 5783

Research Use Only