Product Description

PTPRT Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10144-50, ES10144-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein . at AA range: 200-280

Isotype: IgG

Target: PTPRT,

Specificity: PTPRT Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.

Observed Band (KD): 158kD

Function: Catalytic Activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. May be involved in both signal transduction and cellular adhesion in the CNS. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Similarity: Contains 1 MAM domain. Similarity: Contains 2 tyrosine-protein phosphatase domains. Similarity: Contains 4 fibronectin type-III domains. Tissue Specificity: Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.

Subcellular Location: Membrane, Single-pass type I membrane protein.

Storage and Stability: -20°C/1 year

Gene Name: PTPRT, KIAA0283

Protein Name: Receptor-type tyrosine-protein phosphatase T, R-PTP-T, EC 3.1.3.48, Receptor-type tyrosine-protein phosphatase rho, RPTP-rho

Human Gene ID: 11122

Human SwissProt Number: O14522

Mouse SwissProt Number: Q99M80

Research Use Only