PVRL4 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A16149-20, A16149-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 55kDa
Observed Molecular Weight: 62kDa/75kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 81607
SWISS: Q96NY8
Alternate Names: LNIR; PRR4; EDSS1; PVRL4; nectin-4
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cell Biology Developmental Biology, Cell Adhesion, Tight Junctions.
NCBI Alias: NECTIN4
Research Use Only