Product Description

PYGM Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13846-50, ES13846-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human PYGM AA range: 426-476

Isotype: IgG

Target: PYGM

Specificity: This antibody detects endogenous levels of PYGM at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 93kD

Fields: Starch and sucrose metabolism, Metabolic pathways, Necroptosis, Insulin signaling pathway, Glucagon signaling pathway, Insulin resistance

Function: Catalytic Activity: (1,4-alpha-D-glucosyl)(n) + phosphate = (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate
Cofactor: Pyridoxal phosphate
Disease: Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM: 232600], also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria
Enzyme Regulation: Activity of phosphorylase is controlled both by allosteric means (through the noncovalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B
Function: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all know

Subcellular Location: cytoplasm, cytosol, extracellular exosome,

Storage and Stability: -20°C/1 year

Gene Name: PYGM

Protein Name: PYGM

Mouse Gene ID: 19309

Mouse SwissProt Number: Q9WUB3

Rat SwissProt Number: P09812

Research Use Only