Rabbit Polyclonal Antibody to Human CDNF
Size: 100 µg
Catalogue Number: 300-100
Citations, Manuals and MSDS Available upon request.
Immunogen: Human CDNF
Immunogen Description: Recombinant human CDNF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Purified from cell culture supernatant.
Background: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta
UniProt ID: Q49AH0
Alternative Names: ARMETL1
Clonality: Rabbit polyclonal
Class: IgG
Reactivity: Human, mouse; others not tested
Application: ELISA, WB, IF, IHC-P
Protocol: ELISA 0.1 to 0.2 µg/ml; WB 0.1 to 0.2 µg/ml; IF 0.3 to 2 µg/ml
IHC-P (on formalin-fixed, paraffin-embedded tissues, antigen retrieval) - 5 to 10 µg/ml;
Monoclonal antibody working dilution has to be established practically for each particular antigen and assay format
Purification: CDNF-affinity purification
Buffer: 50% saturated ammonium sulphate in PBS pH 7.4
Shipping: This product is shipped in non-frozen liquid form in ambient conditions
Storage: Store at +4°C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use
Research Use Only