Product Description

Rad23A Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6969-50, ES6969-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: RAD23A, UV excision repair protein RAD23 homolog A, HR23A, hHR23A

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human RAD23A. AA range:91-140

Isotype: IgG

Target: Rad23A

Specificity: Rad23A Polyclonal Antibody detects endogenous levels of Rad23A protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Pancreas, Testis,

Observed Band (KD): 48kD

Fields: Nucleotide excision repair, Protein processing in endoplasmic reticulum

Function: Domain: The ubiquitin-like domain mediates interaction with MJD
Function: Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the RAD23 family
Similarity: Contains 1 ubiquitin-like domain
Similarity: Contains 2 UBA domains
Subunit: Interacts with MJD. Interacts with HIV-1 Vpr

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: RAD23A

Protein Name: UV excision repair protein RAD23 homolog A

Mouse SwissProt Number: P54726

Research Use Only