Product Description

RAGE Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS49578-50, BS49578-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumμlate in vascμlar tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascμlar inflammation in conditions such as atherosclerosis and in particμlar as a complication of diabetes. AGE/RAGE signaling plays an important role in regμlating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellμlar activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Can also bind oligonucleotides. Receptor for amyloid beta peptide.

Category: Primary Antibody

Reactivity: Mouse, Rat

Host: Rabbit

Applications: WB, IP

Alternate Names: RAGE

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of mouse RAGE

Dilution: WB: 1:1000-1:5000 IP: 1:50

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 43 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q62151

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only