Product Description

RAMP3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11934-50, ES11934-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: RAMP3

Specificity: RAMP3 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Strongly expressed in lung, breast, immune system and fetal tissues,

Observed Band (KD): 16kD

Fields: Vascular smooth muscle contraction

Function: Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL
Similarity: Belongs to the RAMP family
Subunit: Heterodimer of CALCRL and RAMP3
Tissue Specificity: Strongly expressed in lung, breast, immune system and fetal tissues

Subcellular Location: Cell membrane, Single-pass type I membrane protein Membrane, Single-pass type I membrane protein Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner

Storage and Stability: -20°C/1 year

Gene Name: RAMP3

Protein Name: Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)

Mouse SwissProt Number: Q9WUP1

Rat SwissProt Number: Q9JJ73

Research Use Only